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The contribution of OS to atopic dermatitis is likely related to the infiltration of the skin with inflammatory cells and cytokines, which promote ROS formation and disrupt the skins antioxidant barrier [197,199,200]

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Thus, CHAC1s role in inducing ER stress and ferroptosis highlights its potential as a therapeutic target to increase the efficacy of DTX in treating castration-resistant prostate cancer ( In vivo experiments confirmed that knocking down miR-432-5p in CAFs enhanced CHAC1 expression, increased ferroptosis, and improved the efficacy of docetaxel in reducing tumor growth