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[2] Two other pathways remain

For example, depression and anxiety occur in up to 60% of patients, while dementia develops in nearly 80% of advanced cases (Panicker et al., 2021

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In an article from Harvard T.H

In contrast, in the FIGHT trial, liraglutide did not show any improvement in clinical stability, outcomes or biomarkers in patients with advanced heart failure and a reduced ejection fraction, suggesting no cerebrovascular or cardioprotective benefits in this group