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In contrast, melanin, which is synthesized by melanocytes, is a true pigment and usually imparts a brown, blue or black appearance to the mucosa

Ozempic, which uses the active ingredient semaglutide, was approved in the US for diabetes in 2017 and subsequently in the UK, and its counterpart for weight loss, Wegovy, was approved in the US in 2021

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Tirzepatide, a newer dual GLP-1/GIP receptor agonist, demonstrated even larger reductions in some studies, with systolic decreases reaching 68 mmHg in overweight patients