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Increases in serum creatinine of greater than or equal to 50% over baseline occurred in 2% of adult subjects receiving phentermine and topiramate extended-release 7.5 mg/46 mg and 2.8% receiving phentermine and topiramate extended-release 15 mg/92 mg, compared to 0.6% receiving placebo

Reflux, Aspiration, and Positioning in Bed Because Wegovy slows digestion, some patients develop reflux or even aspiration episodes at night

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