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PD-L1, programmed death-ligand 1

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Curcumin exerts its antibacterial effects through several pathways: it inhibits bacterial growth, reduces the production of biofilms and virulence factors, blocks bacterial adhesion to host cells, and suppresses the generation of oxidative compounds (246)

So, I think the, I think a good way of kind of breaking it down is to think of the antioxidant defense system in terms of preventing dysregulation and the pathway shutting down is primarily happening at the environment immediately around the mitochondria