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ROS can activate MMPs (including MMP-2) and simultaneously decrease concentrations of TIMPs (including TIMP-2) and this can contribute to BBB permeability (68)

The open conformation of the lid is however different from that previously observed in classical liganded PL, suggesting different kinetic properties for HPLRP2

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PSD95 levels were not significantly affected by sex, diet or GE2 treatment across brain regions Levels of the postsynaptic protein PSD95 were not affected by diet, sex or treatment in the dorsal hippocampus (all p 0.161

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