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In conclusion, this negative feedback loop associated with the above-described thiol-based switch mechanism seems to have been evolutionary favored by the confinement of GSH biosynthesis and of the GCL enzyme in the plastidial compartment of some photosynthetic organisms but not all (or get lost or replaced in some of them)

Infections in such wounds significantly hinder recovery and can escalate to severe complications such as sepsis or amputation [16]

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