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A disturbance in the balance between pro-oxidants and antioxidants leads to oxidative stress, which inflicts molecular harm through free radicals and redox-active compounds (Sies, 2020
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Several studies have shown that ROS affects the cell cycle, leading to cell damage and apoptosis, a process that leads to many types of cancer [2]
Although PPARa over-expression slightly decreased the GSSG/GSH ratio, the change was not statistically significant, suggesting that the reduction in GSSG might be secondary to the alleviation of oxidative stress via the FSP1-CoQ10-NAD(P)H pathway
Overall, short-term garlic supplementation appears to effectively reduce blood pressure with minimal side effects in hypertensive patients