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The depletion of glutathione also plays a critical role in the exacerbation of mast cell activation syndrome (MCAS) and dysautonomia, including postural orthostatic tachycardia syndrome (POTS)

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While the freezing behavior may confound the measurement of acute nociceptive responses measured using classical reflex-based assays, our data from the CPP assay, which assesses the affective-motivational component of pain without relying on motor reflexes, provide additional support for the role of APC GABA neurons in analgesia, particularly within the affective dimension of pain

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P-values indicate comparison between each treatment and control at the 10-week time point

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