Less Common but Serious Side Effects Some less common but more serious GLP-1 side effects are worth being aware of: Pancreatitis (inflammation of the pancreas) Gallbladder problems (including gallstones) Acute kidney injury (usually as a result of severe dehydration from vomiting or diarrhea) Diabetic retinopathy worsening (particularly in patients with rapid improvement in blood sugar control) Hypoglycemia (when combined with other diabetes medications like sulfonylureas or insulin) All GLP-1 medications also carry a warning regarding a theoretical risk of medullary thyroid carcinoma, based on animal studies
Meta-analyses of clinical trials show that GLP-1 RAs, particularly semaglutide, lead to moderate but clinically meaningful reductions in body weight among adolescents with obesity
GLP-1-based therapies have many attractive and beneficial effects including their antidiabetic actions on pancreatic beta-cells
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Many people are turning to GLP-1 medications like Ozempic, Mounjaro, or Foundayo for weight loss
Many people experience side effects from GLP-1 medications, especially in the beginning, including nausea, vomiting, and gastrointestinal discomfort