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Stress, aging, alcohol, smoking, and poor diet shift the ratio toward GSSG and lower your antioxidant defense

doi: 10.1128/iai.64.9.3703-3712.1996 122 MackenzieG

Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo

3 Synergistic pathogenic mechanisms of ferroptosis in DR 3.1 Vicious cycle mechanism of oxidative stress-BRB injury-ferroptosis Oxidative stress is defined as an imbalance between reactive oxygen species (ROS) and the endogenous antioxidant defense system, and the retinal tissue and cellular damage it mediates serves as a core pathological driver of diabetic retinopathy (DR) progression (151)

Overall, further research is necessary to establish the stability of the models in terms of consistency and reproducibility