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One of my patients (compound heterozygous MTHFR) had chronic pitting edema that resolved around 3 weeks of use

TRPV3, transient receptor potential vanilloid 3 channel

Though the normal intestinal microbiome does not include large amounts of pathogenic organisms, as an example, increased proliferation of the pathogen Clostridium botulinum is associated with release of botulinum neurotoxins, damaging the intestinal barrier and fostering absorption of the neurotoxin into the systemic circulation and the nervous system, causing botulism [49]

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