Conversely, OTC drugs are frequently limited by their milder efficacy and regulatory constraints, which restrict their use for more severe or complex obesity cases
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With these assumptions, 1840 participants randomly assigned to semaglutide or placebo will provide 95% power to confirm superiority of semaglutide for the primary endpoint (change from baseline to week 104 in CDR-SB score)
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While concerns over the negative health impacts of obesity remain, they are now in competition with concerns about the high cost and proper use of GLP-1 agonist medications, particularly at a time when other cost pressures may be growing