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for those participating in CKD trials, mean BMI 35.435.7 kg/m 2 versus 31.2 kg/m 2 in those not on GLP-1 RAs)

10.1080/17474124.2023.2172397 22 GuoT.YanW.CuiX.LiuN.WeiX.SunY.et al (2023)

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Overall, preclinical and clinical data align in demonstrating CV protective effects of GLP-1RAs particularly with respect to vascular protection and heart failure (predominantly HFpEF), while some uncertainties remain regarding the magnitude of benefit on HFrEF-related endpoints and the specific mechanistic pathways involved

Training at least 3 times per week is ideal