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DEM, an - unsaturated carbonyl electrophile known to be detoxified by GST catalysis using GSH as a cofactor, was used to mimic the depleting ability of TNBS

J Clin Oncol 34(suppl), 2016

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Addition of the ISR agonist Sephin1 to cultured human OLmaintained under control conditions or exposed to ongoing metabolic stressreduced process outgrowth 42 , suggesting that the ISR regulates the protein synthesis machinery required for OL process outgrowth and maintenance

Shi Q, Wang CL, Zhang H, Chen C, Zhang X, Chang X-L