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The small molecule, genistein, increases hepcidin expression in human hepatocytes

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In addition, mitoglitazone significantly alleviates renal I/R injury in mice by upregulating GPX4 and reducing iron-related lipid peroxidation

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Oxidative inactivation of redox sensitive cysteine residues in Keap1, specific phosphorylation of Nrf2, or increased expression of p62, which competes with Nrf2 for Keap 1 binding, disrupts the Keap1/Nrf2 interactions to foster the stabilization and nuclear translocation of Nrf2 where it promotes transcription of a variety of protective antioxidant genes via the antioxidant response element or ARE in their promoter regions