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Lipid-based vesicles are used for agent delivery, because they are able to cross the cell plasmatic membrane and have low cytotoxicity, but there are other more effective delivery systems available, such as nanoparticles, e.g

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Zhou et al., Gold nanoparticles impair autophagy flux through shape-dependent endocytosis and lysosomal dysfunction

To date mutations in at least 12 different genes have been shown to contribute to type 2 RTA

doi:10.1248/bpb.27.956

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