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Hoffman DJ, Heinz GH (1998) Effects of mercury and selenium on glutathione metabolism and oxidative stress in mallard ducks

In a phase II dose-finding trial, semaglutide was evaluated as an anti-obesity medication, demonstrating superior weight loss efficacy when administered once daily subcutaneously compared to both placebo and once-daily 3.0 mg liraglutide in patients with obesity but without T2DM

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PMID: 26147225, PMCID: PMC4493110, DOI: 10.1371/journal.pone.0132470

They are well-tolerated but their ability to lower blood sugar is modest and they generally do not cause weight loss