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Its mechanism of action is primarily mediated by its role as a substrate for NAD + -dependent enzymes such as the sirtuin family (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and certain ectoenzymes like CD38 and CD157

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The improvement was maintained until week 28, three months after treatment ended

The peptide derives from a protein found naturally in human gastric juice, and it has been studied extensively for its protective and regenerative effects across multiple tissue types

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The lower esophageal sphincter (LES) is a ring of muscle that acts as a valve between the esophagus and stomach