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A phase 1B trial involving 20 people showed MOTS-c was safe, but the project didnt move forward because to get the kind of response that we wanted that was clear and substantial it needed to be given at least daily, maybe twice a day, at a pretty large volume, and it was clear that thats not going to be a way to develop a drug, said Cohen, a professor of gerontology, medicine, and biological sciences and dean of USC Leonard Davis School of Gerontology in Los Angeles

Caloric restriction and L-carnitine administration improves insulin sensitivity in patients with impaired glucose metabolism

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Both Retatrutide and GHK-Cu use this route