LIRA and SEMA gained approval from the Food and Drug Administration and the European Medicines Agency for weight loss in obese individuals or people who are overweight with BMI 27 kg/m 2 and have experienced at least one weight-associated comorbid condition (such as prediabetes, hypertension, dyslipidaemia, and OSA) combined with lifestyle modifications [63]
Treatment indications continue to expand The mechanisms underlying incretin-based therapies remain incompletely understood
However, the next phase of translational research must now broaden its scope
Mecanismo de accin de GLP-1: Estimulacin de insulina dependiente de glucosa : GLP-1 aumenta la secrecin de insulina del pncreas solo cuando los niveles de glucosa estn elevados, reduciendo el riesgo de hipoglucemia (azcar baja en sangre)
The company was recently suspended from membership
However, this practice lacks clinical evidence and regulatory approval