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Feeling Worse After B12 Injections Usually, this phenomenon occurs within the first few weeks of starting with the B12 shots

Some patients feel better for several weeks, while others experience improvements for months

Rarely patients may develop low blood sugar, but this is not common with therapeutic errors

Research indicates preferential accumulation in actively dividing cells and tissues with high metabolic activity, including dermal fibroblasts, keratinocytes, and endothelial cells

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Because intramuscular B12 is absorbed more slowly over a longer time frame than intravenous delivery, each shot offers a sustained elevation in serum levels between appointments