Positive airway pressure (PAP) therapy adherence is lower among COMISA patients, and even new obstructive sleep apnea (OSA) medications list insomnia as a common side effect
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As a result, for women on oral birth control, its recommended to switch to a non-oral contraceptive method or add a barrier method of contraception for 4 weeks after initiation and for 4 weeks after each dose escalation
They also make appetite control stronger as doses go up, which helps keep long-term results manageable
FDA is aware of some instances in which patients have been given syringes that are significantly larger than the prescribed volume of semaglutide (see example in Figure 1)
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