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Exenatide had 53% homology with GLP-1, had strong binding ability with GLP-1 receptor and was not easily degraded by DPP-4

GLP-1 medications work by slowing down digestion, which can sometimes lead to nausea or digestive discomfort

You may not be familiar with GLP-1 terminology, but Im sure youve heard of the brands

Medications for Nausea and Vomiting (OTC: Over-the-Counter) Meclizine (Bonine) OTC at low doses (25mg), prescription for higher doses (50 mg or more) Dimenhydrinate (Dramamine) OTC Nauzene-OTC Pepto-Bismol-OTC Dramanine-OTC Emetrol OTC Ondansetron (Zofran) by prescription (check with your doctor, it can cause constipation, a GLP-1 side effect) Metoclopramide (Reglan for GERD) by prescription (check with your doctor, it is used to treat gastroparesis which means it increases gastric emptying

Excessive autophagy is another cause of vascular aging

The presence of primary cilia on islet cells is conserved across species (13) and has been shown to be critical for signaling of specific GPCRs to regulate islet insulin and glucagon secretion (14)