Wang P et al
Harshbarger argued in the letter that the FDA has been too strict, which has led peptide users to sketchier sources: Yet FDA policy significantly restricts compounding of these peptides even where no FDA approved alternative exists leaving patients without safe, regulated access
However, these risks can also be exacerbated by CYP genetic polymorphisms and liver diseases, which may increase the production of potentially hepatotoxic drug metabolites (108, 109)
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Because it is largely free of those binding proteins, the analog stays active far longer than native IGF-1 a substantially extended half-life and more sustained systemic exposure
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