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Lixisenatide, a GLP-1R agonist, reduces neurofibrillary tangles and amyloid plaque load, and thereby ameliorates learning memory deficits in APP/PS1 mice (144, 157)
There is not enough research to confirm causation, he continued
But yeah, when you look at MCAS and so you look at mast cell, I think what we really have to look at That is, we have to be so careful to understand the nuances of what is actually an activation issue for this individual
In STEP 1 [1] , the largest trial with 1,961 participants [1] , patients receiving semaglutide 2.4 mg weekly achieved an average weight loss of 14.9% over 68 weeks, compared to 2.4% with placebo (Wilding et al., NEJM, 2021)
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