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GPNMB expression was also increased in senescent human umbilical vein endothelial cells, in endothelial cells from old mice, and in several other tissues such as bone marrow and lungs 62 , suggesting that GPNMB could be a potential target in senescence-related pathological conditions

This drug is being tested in clinical trials conducted with depressed and chronic pain patients but not AD [29]

Zhang J, Grek C, Ye ZW, Manevich Y, Tew KD, Townsend DM

PMID: 70 LiSShengZH