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Frequent use can cause severe electrolyte imbalances and even death.

In December 2025, Eli Lilly published the first positive Phase 3 readout for retatrutide (LY3437943), the triple-agonist peptide that had, until then, only been validated at Phase 2 scale

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A study showed that schisandrol A has an active antidepressant effect on lipopolysaccharide induced depression in mice by regulating intestinal microbiota and inhibiting TLR4/NF-B signal pathways in the hippocampus to reduce neuroinflammation (48)