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What are PPS reporting on in Domain 4
While low to moderate levels of ROS are essential in various physiological processes, their excessive and uncontrolled production causes failure of endogenous defences, leading to oxidative stress (OS) and possibly causing damage to the proteins, lipids, and DNA
These IR-induced mitochondrial defects are evident in both insulin-sensitive tissues (liver, muscle) and in the heart and brain, providing a mechanistic link between metabolic dysfunction and cardiovascularcognitive comorbidity
Agsin in their guidelines
Yonago Acta Med
Systematic Review Orthopaedic Sports Medicine (2025) The 2025 systematic review by Vasireddi, Hahamyan et al
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