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Similarly, the increase in cholesterol load alone also seemed to promote the appearance of ASC specks (although in that case, changes did not reach statistical significance at an level of 0.05)

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doi:10.1016/j.tibs.2006.11.006 Guse AH

Lesions generally begin with defective hair follicle maturation, resulting in occlusion and rupture

This change was attributed to an increase in the control groups levels, while the eTRF groups levels stayed consistent