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493 A randomized open-label phase III clinical trial evaluating the efficacy and safety of T-VEC compared with GM-CSF revealed promising durable clinical benefits with a higher ORR (31.5% vs 6.4%), higher durable response rates (19.0% vs 1.4%), and longer median OS (23.3 months vs 18.9 months) versus GM-CSF alone, as well as favorable safety profile, especially in IIIB-IVM1a melanoma patients

Cons: Similar to Ozempic and Wegovy, Zepbound requires regular injections, which may be inconvenient for some patients