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Tolerance: Some studies indicate DSIP does not appear to induce pharmacological tolerance with continued use [2]

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Furthermore, ghrelin levels were found to be significantly lowered in individuals with autoimmune gastritis who exhibited delayed gastric emptying and impaired autonomic function

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However, as for other peptide hormones, their clinical application is limited by their short circulatory half-life, a major component of which is cleavage by DPP-IV

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