ER17p functions as an inverse agonist of GPER in SkBr3 breast cancer cells [273], not only by inhibiting GPER-mediated transactivation of EGFR and reducing the phosphorylation of ERK1/2 and c-Fos [274] but also by inducing the ubiquitin-mediated degradation of GPER, thereby decreasing its membrane expression levels [275]
10.1097/01.mpg.0000170600.80640.88 102 SoresiM.SparacinoV.PisciottaG.BonfissutoG.CaputoF.CarroccioA.et al (1995)
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