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Acute musculoskeletal injuries (tendon strains and muscle tears) show functional improvement from 2 to 4 weeks, while full collagen remodeling requires 4 to 6 weeks of consistent administration

This scoring system allowed for semi-quantitative evaluation of cartilage integrity based on macroscopic features such as softening, fibrillation, erosion, ulceration, and complete cartilage loss [1]

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