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Musculoskeletal symptoms: Joint pain (arthralgia), muscle aches, peripheral edema (mild swelling) [9]

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This produces a tanning effect with minimal UV exposure, and the effect is systemic, resulting in full body darkening

10.1016/j.jpba.2022.115109 12 HooijmansC

Most people begin to feel improvements in energy and mental clarity within a few days, though mood, nerve, and red blood cell benefits continue to build over several weeks

Notably, discontinuation is associated with weight regain and partial or complete reversal of improvements in cardiometabolic risk factors, including inflammatory markers, blood pressure, lipid profile, and blood glucose levels