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the study physician attributed the death to pre-existing coronary artery disease unrelated to the drug, but the FDA's Pharmacy Compounding Advisory Committee cited this "unresolved cardiac signal" in December 2024 as a reason to keep the compound off the approved compounding list

Cochrane Database of Systematic Reviews

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Tirzepatide works by activating both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor

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Loss of control: adjusting one variable becomes impossible when both peptides depend on each others concentration