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Given the difficulty with lifestyle changes such as diet, there is a need for alternative treatments for treating NAFLD

2010 Apr;151(4):1473-86 Madsen LW, Knauf JA, Gotfredsen C, Pilling A, Sjgren I, Andersen S, Andersen L, de Boer AS, Manova K, Barlas A, Vundavalli S, Nyborg NC, Knudsen LB, Moelck AM, Fagin JA

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doi: 10.1136/gut.38.6.916 23 RanganathLNorrisFMorganLWrightJMarksV

As noted, endogenous GLP-1 has a very short half-life of 12 min because it is rapidly degraded by the enzyme DPP-4, which results in low systemic levels