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In this model, the deficiency of GPx1 caused excess vascular superoxide and decreased bioavailable nitric oxide, and vascular injury by balloon angioplasty and stenting increased the expression of GSH enzymes, with a corresponding increase in GSH and the GSH/GSSG ratio

Therefore, compound 8u may be a potentially effective xanthine oxidase inhibitor for the treatment of hyperuricaemia with low toxicity (Zhang et al., 2019)

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Publications Safety and efficacy of laquinimod for Huntingtons disease: LEGATO-HD a multicenter, randomized, double-blind, placebo-controlled phase 2 study