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However, these usually do not affect the quality of the product
Although hepatitis has been observed with extended-release nicotinic acid at dosages as little as 500 mg/day for two months, almost all reports of severe hepatitis have been associated with doses of 3 to 9 g/day used to treat high cholesterol for months or years (41)
et al., 2018) and gallstone disease (Zhou et al., 2005
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