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The latter event has a crucial role in supporting cell proliferation and cell cycle progression via ERK5 transcriptional activity [35,36,37]

As summarized in Table 1 , the compound exerts potent effectsincluding inhibition of proliferation, induction of apoptosis, suppression of CSCs, and modulation of the tumor immune microenvironmentacross diverse cancer types

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Conversely, when cells were treated with hemin, an inducer of HO1, radiation-related DNA damage decreased by nearly 50% [33]

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After centrifugation, the NPCs pellet was re-suspended with binding buffer and incubated with the Annexin-V and PI antibodies mixture for 15 min, according to the manufacturers protocol