In a mouse model of acute inflammation in vivo , with the treatment of sommarutide, circulating concentrations of pro-inflammatory cytokines, including TNF- and IFN-, were decreased, accompanied by attenuated infiltration of immune effector cells ( 2.2.1 Autophagy Autophagy is an evolutionarily conserved catabolic process essential for cellular homeostasis during stress conditions, including nutrient deprivation and hypoxia
Semaglutide mimics the action of GLP-1, stimulating insulin secretion, inhibiting glucagon release, and slowing down digestion, all of which contribute to better blood sugar control
Researchers noted that their study supports the results of smaller, earlier studies on GLP-1 drugs and heart failure
In these large trials, most participants on GLP-1s lost over 10% of their initial weight after approximately a year
Lee WJ, Chen CY, Chong K, Lee YC, Chen SC, Lee SD
2021;320(4):G61726