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The Broader Implications of GLP-1 in Addiction Treatment Targeting Reward Pathways One of the most significant findings in addiction research is how addictive substances modify the brains natural reward system, often in a way that is difficult to reverse

This reflects the chronic nature of obesity rather than medication failure

The SURMOUNT-5 clinical trial published in The New England Journal of Medicine showed that Zepbound (tirzepatide) achieved an average weight loss of 20.2% compared to 13.7% with Wegovy (semaglutide) at 72 weeks

303 , F963F971 (2012)

Getting the dosing right for whichever medication class is being studied is step two

34 Trials have been conducted for other outcomes, such as breast cancer and neurodegenerative disorders