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Comparing biological markers of Alzheimer's disease across blood fraction and platforms: comparing apples to oranges

In contrast to human tissue and cultured cells, it has been demonstrated that Nrf2 activity is consistently elevated in the spinal cord of SOD1 G93A rodent models of ALS, and the increase of Nrf2, thioredoxin, HSP-70, HO1, NQO1, GCLC, and GCLM protein levels follows disease progression in the lumbar spinal cord but not cortex [264, 265]

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Subcutaneous injection near injury sites or systemic administration both show effectiveness

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