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These findings, together with comparative structure analysis, time-lapse microscopy, and phosphoproteomics, reveal unique signaling signatures for GLP-1R agonists at the level of receptor conformation, functional selectivity, and location bias, thus associating signaling neighborhoods with functionally distinct cellular outcomes and clinical consequences

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Glucagon-Like Peptide-1 Enhances Glucokinase Activity in Pancreatic beta-Cells through the Association of Epac2 with Rim2 and Rab3A

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