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For diabetes management, alternatives include SGLT-2 inhibitors, DPP-4 inhibitors (which should not be combined with GLP-1 medications), metformin, and insulin when necessary

The formation of ice crystals can physically damage the peptide structures

The creation of new mitochondria by PQQ occurs through the activation of CREB and PGC-1alpha, pathways known to increase mitochondrial biogenesis [25]

Hansen JC, Deguchi Y

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