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Description

Proper titration greatly reduces GI side effects while keeping effect

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ABCA1: ATP-binding cassette transporter A1

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While the other B vitamins are water-soluble and absorbed into the bloodstream from the gut, vitamin B12 must first bind to a protein called intrinsic factor (IF) produced in the stomach before it can be absorbed

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The numerous side effects of these drugs often lead to patients discontinuing treatment, making long-term compliance a real problem

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