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One intriguing possibility is that cerebral folate deficiency under normal blood folate levels caused by the impaired transport of folate across the bloodbrain barrier (Frye et al., 2020), leads to homocysteine accumulation (Ramaekers et al., 2014)

doi: 10.21037/tau.2019.11.30

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Kortman et al., 2012

Mast cells are activated upon allergen-induced cross-linking of FcRI-bound IgE on their plasma membrane surface