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[1] [2] This occurs because B12 deficiency commonly affects the peripheral nerves, particularly those extending to the extremities

This leads to the amplified release of growth hormone (GH) due to the coordinated action of the hypothalamus as well as the pituitary gland

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Dietary modifications help significantly

In rats, it may be activated by peripheral signals, such as distension of the stomach that activate the GLP-1expressing neurons of the NTS, 28 and it has also been associated with enteroceptive stress

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