Dry powder can tolerate brief periods at room temperature, up to several weeks, without catastrophic degradation
Semaglutide is a GLP-1 receptor agonist medication that helps men lose weight by mimicking a natural gut hormone called glucagon-like peptide-1, which regulates appetite, slows digestion, and improves blood sugar control
We excluded 1) those with diagnoses of AF, atrial tachycardia, ventricular tachycardia, ventricular fibrillation, mechanical valve, hyperthyroidism, or mitral stenosis before or on the index date, 2) those with cardiac events (i.e., myocardial infarction, percutaneous intervention, valve/bypass surgery) in the preceding 3 months, 3) those currently receiving antiarrhythmic medications (e.g., amiodarone, dronedarone, flecainide, propafenone, or dofetilide) on the index date, 4) those who used insulin within one year prior or on the index date, and 5) those who do not have hemoglobin A1C (HbA1c) within one year prior or on the index date (eFigure 1)
Patients must enroll in the iPLEDGE program to receive their medication from the pharmacy
Mozaffarian D, Agarwal M, Aggarwal M, et al
Freezing reconstituted GHK-Cu isn't ideal because ice crystal formation can damage peptide structure
