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10.1007/s12010-019-03009-x 23

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2,3 This interaction is associated with several biological processes involved in maintaining skin health, collagen support, healthy hair, immune function, and angiogenesis (the formation of new blood vessels) 1-3

Since the haem-binding affinity of PGRMC1 is lower than those of constitutive haem-binding proteins such as myoglobin, PGMRC1 is probably interconverted between apo-monomer and haem-bound dimer forms in response to changes in the intracellular haem concentration